New Multi-functional probes of Fe5C2 nanoparticles
时间:2014-04-20 点击:

 

          Recently, Professor Yanglong Hou’s group in the Department of Materials Science and Engineering, College of Engineering, has made new advances in cancer diagnostics and therapy based on Fe5C2 nanoparticles. The work has been published in Advanced Materials (Y. Hou et al. Adv. Mater. 2014, http://onlinelibrary.wiley.com/doi/10.1002/adma.201305811/abstract), and highlighted by Material Views(http://www.materialsviews.com/iron-carbide-nanoparticles-a-new-platform-for-tumor-theranostics/).

        Multifunctional nano-probes for simultaneous diagnostics and therapeutics are promising for their potential in overcoming cancer-related diseases. By integrating imaging agent and therapeutic composite within one nanoparticle, diagnosis of certain disease, curing it, and monitoring the follow-ups can realize after only one injection. This strategy can help doctors to make therapeutic schedule individually, and find the optimal time for treating as well as the dose used.

      As a minimal invasive local cancer therapy, photothermal therapy is a cancer-cell “burning” treatment by transferring light into heat that can flexibly control the curing spot and intensity. With further transforming the resulted heat into ultrasound wave, probes for photothermal therapy are usually allowed to serve as contrast agents for photoacoustic tomography. On the other hand, magnetic materials are usually applied in magnetic resonance imaging, which is a clinically widely used diagnostic method with high sensitivity. By facilely synthesizing Fe5C2 nano-structure by a one pot process, Yanglong Hou’s group successfully combined the light absorption and magnetic property within one nanoparticle. The probe exhibits high magnetic property and shows improved contrast ability than commercially available agent. Moreover, improved the stability as well as superior in photoacoustic tomography and photothermal therapy can be realized due to the carbon shell coating. After conjugating with affibody, which can target to certain tumors, the probe can orientate parts needed, and cure it under the irradiation. This work highlights the great potential of Fe5C2 nanoparticles as multifunctional probes for imaging-guided cancer therapy with low side effect.

      In addition, the group also presented the chemical synthesis of Fe5C2 nanoparticles, and investigated their application in the catalysis of Fischer−Tropsch synthesis. Compared with a conventional reduced-hematite catalyst, it showed enhanced catalytic performance in terms of CO conversion and product selectivity. This work has been published in Journal of the American Chemical Society (Y. Hou et al. J. Am. Chem. Soc. 2012, 134, 15814).

      These projects are supported by the National Natural Science Funds for Distinguished Young Scholar and the General Programs of the National Natural Science Foundation of China. 

 

 

 

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